RTSUN - SP

P. Falciparum causes life threatening form of Malaria and unfortunately this species of Malaria has already developed resistance to a number of drugs including chloroquine , Quinine , Mafloquine and others. In case of severe and acute Malaria, the parasite load becomes so enormous that it would certainly affect the metabolism of the patient quiet adversely who might ultimately die. Hence, there is a need to reduce the parasite load embedded inside the RBC as fast as possible otherwise with the fall of hemoglobin and iron, respiratory depression will certainly develop followed by severe hypotension and hypoglycemia since sugar is also bound to RBC.

The above conditions are really serious and should be treated aggressively. In order to reduce the parasite load and faster return to normal body temperature.

WHO, now recommends the use of Artesunate Tablets 4mg/kg for 3 days once daily i.e. 200mg for DAY 1, 200mg for DAY 2 , 200mg for DAY 3. On Day 1 along with 3 tablets of Sulfadoxine + Pyrimethamine which contains 500mg of Sulfadoxine and 25mg of Pyrimethamine respectively. (Dose being 25mg per kg body weight of Sulfadoxine and Pyrimethamine 1.25mg/kg for adults), two tabs of artesunate each of 100mg is to be administered.

Through many trials WHO recommends this regimen is suitable for high endemic areas of P.Falciparum Malaria where the species is still susceptible to SP.

CDEF - LB

Cefpodoxime Proxetil even though belongs to a group of Cephalosporin containing the Beta-lactum ring but normally it is very rare to see a number of drugs which act as Prodrug to the human system, thus delivering a massive efficacy against the pathogens , Here also Cefpodoxime Proxetil when administered is exposed to non specific esterases which hydrolyze the clevable ester, thus releases the Cefpodoxime which acts as the PRODRUG.

It is absorbed from the Proximal Intestine with sustained Plasma Levels in Humans . It delivers potent antibacterial activity against LRTI, Pathogens, Haemophilus influenzae, moraxella and many g,+ve, gm-ve pathogens associated with common paediatric infections, making CDEF –LB a very useful antibiotic for EMPIRICAL THERAPY.

CDEF-LB contains also 40million spores of Lactobacillus which undoubtedly helps strengthen intestinal microflora stimulating the normal metabolism.

This type of drug is always preferable to be used in any paediatric group where diagnosis is not immediately possible . In such Circumstances CDEF-LB can be used without even giving a serious thought to the problem. This is a best type of approach in the treatment of patients as nomenclated as EMPIRICAL THERAPY.

TINYMOL

Pyrexia or fever if continued for a longer time could seriously affect the metabolism particularly in the brain . Hyperpyrexia if not controlled in the shortest possible time might lead to convulsions in the paediatric group Which will result in many complications unless the fever is controlled aggressively.

We are presenting The Brand TINYMOL with two strong inhibitors of Cyclooxygenas,thus preventing fever. TINYMOL consists of Acetaminophen 125mg and Nimesulide 50mg in each 5ml of 60ml bottle.A strong antipyretic effect is delivered. Through inhibition of Cyclooxygenase by the oxidized form of Acetaminophen in the Brain, which also inhibits COX 3 only found in the Brain. This helps in reduction of fever further , the cyclooxygenase available in the Peripheral is strongly inhibited by Nimesulide . This additive effect helps to reduce hyperpyrexia at the shortest possible time.

Thus the Brand complies with the objective of controlling fever in the treatment of paediatric group.

DEL – 50

We considered marketing a product under the Brand Name Del-50. A discreet analysis of the market segment revealed a very high Potential for an antiulcerant in India.

The Brand is manufactured under high tech process. It is presented in Pallets in a transparent capsule  containing  extended  release orange Colour 20mg Rabeprazole, the second  one is white  Domperidone immediate Release and the third one is brown  20mg Domperidone entric coated formulation.

Rabeprazole is a substituted benzamide that gets activated in the acidic environment. It acts by inhibiting the enzyme H+K+ATPase in a dose dependent manner, reducing both basal and acid peptone stimuted secretions with 20mg daily doses to provide optimal anti-secretary effects in healthy volunteers. The drug has a similar or faster onset of action than omeprazole and Pantaprazole . In addition, Rabeprazole has a greater antisecretary effect over a period of 24 hours then esomoprazole, Lansoprazole and pantaprazole. In ulcer healing , while superior to Ranitidine or Placebo , long term studies, similarly , have established its safety and efficacy.

Short term treatment of erosive or ulcerative esophagitis in Patients with GERD. Also used for maintenance therapy following healing of erosive esophagitis  to reduce recurrence (4 weeks).   

Proton Pump Inhibitors (PPIs) which act by blocking the enzyme System responsible for action transport of Proton into gastrointestinal Lumen  namely the Hydrogen/ Potassium adenosinc triphosphatase (H+K+ATPase)  of the gastric parietal cells, also known as the ‘Proton Pump’ (Proton is a name used for Preparations of different composition). Gastro-esophageal reflux disease, gastric or Duodenal ulcer ,  zollinger – Ellison Syndrome  & Prophylaxis of NSAID induced peptic ulcer.

Zollinger – Ellison Syndrome; a rare disorder in which there is excessive secretion of gastric  juice because of high  level of circulating ‘gastrin’ which is produced by pancreatic Tumour (benign or malignant gastrioma) or an enlarged Pancreas producing excess gastrin .The  high levels of stomach acid cause peptic ulcers which may be  multiple at unusual sites e.g. Jejunam, GERD, PEPTIC  ULCER  , DUODENAL ULCER.

 

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